Saeed Zafar Khan, Zahid Kamal Sidduqi, Akram Riaz.
Analysis of Visual Outcome & Safety of Laser-Assisted Sub-Epithelial Keratectomy (Lasek) for the Treatment of Moderate to Severe Myopia & Myopic Astigmatism by using Mitomycin?C.
Ophthalmol Update Jan ;12(3):182-5.

Purpose: The purpose of this study was to report the visual outcomes and rate of complications of laser assisted subepithelial keratectomy(LASEK) for the treatment of myopia up to -12.00 diopters spherical and Myopic astigmatism of up to -3.50 diopters by using intra -operative 0.02% Mitomycin C. Materials and Methods: A prospective case series of 64 eyes of 32 patients who under went the laser sub-epithelial keratectomy for the treatment of myopia were studied. Parameters for study included Preoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), Mitomycin C concentration and exposure time, pain, corneal haze and epithelial healing. Results Mean baseline spherical equivalent refraction was ranged -3.75 to -12.50+? 3.50 diopters. Pre operative best corrected vision ( BCVA) was 6/9 or better in 46(71.8%) eyes and 12 (18.7%) had 6/9 to 6/12 whereas 6 (9.3%) eyes had visual acuity of less then 6/12. Mean spherical equivalent refraction after lasek surgery was +_ 0.75 diopter .At last follow up post laser un -corrected visual acuity (UCVA) was 6/9 or better in 52 ( 81.2% ) eyes, 8 (12%) eyes had 6/9 to 6/12 while 4 (6.4%) eyes had visual acuity of 6/12 or worse. Complete epithelialization and removal of bandage contact lens took place in 4.75 +- 2.89 days (range was 3 -8 days). At the last follow up visit of patients 50 (78%) eyes had clear cornea and Grade I haze developed in 7 (10.9%) eyes whereas Grade II haze was seen in only 2 eyes (3.1%), none of the eyes developed grade III or IV haze. Conclusions: Laser sub epithelial keratomelisus with intra operative application of 0.02 % mitomycin c was effective and safe procedure which resulted in excellent visual outcomes with few complications.

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