Atif Mansoor Ahmad, Mohammad Saeed, Arshad Mahmood.
Topical Nepafenac Vs Ketorolac for Maintenance of Intra-operative Mydriasis in Phacoemulsification.
Ophthalmol Update Jan ;12(4):282-5.

Purpose: To compare the efficacy of pre-operative use of topical nepafenac 0.1% and ketorolac 0.5% on maintaining mydriasis during phacoemulsification with foldable IOL implantation. Material and Methods: This prospective, randomized and masked comparative study involving senile cataract patients given topical NSAIDs (nepafenac or ketorolac) or balanced electrolyte solution (control) prior to phacoemulsification. In all patients phacoemulsification was done with capsular bag intraocular-lens (IOL) implantation at Sheikh Zayed Hospital, Lahore. Horizontal and vertical diameters of pupil were measured at different stages of cataract surgery and the mean values were recorded. Results: A total of 94 eyes of cataract surgery patients, 26 males and 68 females with a mean age of 68.36 ± 7.07 years, were included in the study. The mean horizontal and vertical diameters of the all groups were similar at the start of surgery. Significant differences were seen after IOL implantation, with the nepafenac group having the largest mean diameters in both horizontal and vertical pupil measurements. Conclusion: Topical nepafenac has been shown to be a more effective in maintenance of mydriasis during phacoemulsification and provides a more stable mydriatic effect throughout the surgical procedure compared to topical ketorolac and placebo.

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