Hussain Ahmad Khaqan, Farrukh Jameel, Hadia Jabeen, Muhammad, Usman Imtiaz.
Tuberous Sclerosis Complex.
Ophthalmol Update Jan ;13(2):82-4.

Tuberous sclerosis complex (TSC) is an autosomal dominant neuro-cutaneous disease (phacomatosis) with variable clinical manifestations.1 The incidence of the disease is approximately 1/6000- 1/10000.2,3 Diagnosis is based on clinical and para-clinical criteria defined by the tuberous sclerosis consensus conference in 1998. There are two groups of symptoms including major and minor criteria. The major criteria consist of: Facial angio-fibromas or forehead plaques, Non-traumatic ungula or periungual fibroma, Hypo-pigmented macules (more than 3), Shagreen patch, Cortical tubers, Sub-epandymal nodules, Sub-epandymal giant cell astrocytoma, Multiple retinal nodular hamartomas, Cardiac rhabdomyoma, Lymphangio-myomatosis and renal angio-myolipoma.

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