Farhat-ul Ain, Attiqa Amin, Farah Yasmin.
Hepatitis in Pregnancy.
Proceeding Shaikh Zayed Postgrad Med Comp Jan ;21(1):11-4.

Objective: To determine the frequency of viral hep'atitis in general, spectrum of hepatitis E in particular, and to study the maternal and fetal morbidity and mortality associated with it. Design: Observational study. Place and Duration of Study: Fatima Memorial Hospital, Lahore from Jan06 to Sept 2006. Patients and Methods: In this prospective study, total number of pregnant women was 4723, sera of 35 pregnant women having clinical jaundice in pregnancy were analyzed for markers of hepatitis A, B, C and E viruses. Results: Of the 35 pregnant women with jaundice HEV IgM were 60%,HA V IgM20%,Anti HCV 8.75%, Hbs Ag 5.71 %, unexplained 5.71 %.Amongst HEV 23.80% had hepatic encephalopathy, DIC in 42.85%, PPH in 23.80%,renal failure in9.52% an- maternal mortality in 4.76%. Approximately two third of pregnant women with HEV infection had preterm deliveries (76.19) % and perinatal mortality of 42.8%. Conclusion: Hepatitis E was the commonest etiological agent in those who had fulminant disease during pregnancy and was associated with high morbidity and mortality.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com