Syed Wasif Ali Shah, Pervaiz Iqbal, Hamid Qayum.
Evaluation of the Results of Giant Cell Tumor of Bone Treated with Curettage and PMMA Packing.
Proceeding Shaikh Zayed Postgrad Med Comp Jan ;23(2):97-103.

Giant cell tumor is an aggressive destructive epiphyseal lesion characterized by abundant multinucleated giant cells, accounting for some 5% of Prim Bone Tumours. This study was conducted to see to functional outcome after intralesional excision, chemical adjuvant of phenol and augmentation with PMMA packing. Material and Methods: Thirty patients of Companacci grade I and II were selected and operated with intralesional excision and PMMA packing. They were followed for 5 years. Final evaluation consisted of physical examination and radiographic evaluation. Results: Majority of the patients (80%) were from 3rd and 4th decades of life. There was slight male preponderance 55% and chief presenting complaints were pain and swelling (79%). The mean duration of symptoms was 8.4 months and 13 (65%) patients had lesions around knee either prox. Tibia and distal femur. Thirty percent patients were having grade I and 70% grade II lesions. Complications included recurrence in 10% limited range of motion 20%, superficial bone infection 10% and pain being most common 55% of patients. Otherwise overall fair to excellent results are seen. Conclusion: Majority of patients with giant cell tumour of bone can be treated satisfactorily with intralesional excision technique coupled with adjuvant treatment. Bone cement carrying advantage over conventional bone grafting, as it acts as spacer, fills the gap, gives stability and acts as cytotoxic agent killing remaining tumor cells. Furthermore it does not carry morbidity of graft harvesting.

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