Sadia Maqsood Awan, Saadia Shahzad Alam, Abdul Hameed Khan.
Effect of Ficus Carica Leaf Extract on Cardiac Enzymes: A Study on Doxorubicin Induced Cardiotoxicity.
Proceeding Shaikh Zayed Postgrad Med Comp Jan ;24(1):73-7.
Objective: We have conducted a study to evaluate the protective effect of Ficus Carica (Anjiir) leaf extract on elevated levels of cardiac enzymes due to Doxorubicin toxicity in rats. Material and Methods: 30 Albino rats were divided into 3 groups of 10 each, one of which was control group. The 2nd group received intraperitoneal Doxorubicin, while the third also had oral feed of Ficus carica leaf extract following Doxorubicin injection. Blood was drawn after 10 days by cardiac puncture and serum was prepared for estimation of serum Lactate dehydrogenase (LDH), Creatinine phosphokinase (CPK), Aspartate transferase(AST), serum sodium and serum potassium levels. Results: Administration of Ficus carica leaf extract via oral route after the intraperitoneal injection of Doxorubicin produced significant decline in serum CPK and LDH levels with p?0.05. Conclusion: Ficus Carica leaf extract has shown to possess protective effect on cardiotoxicity of Doxorubicin by decreasing the elevated levels of cardiac enzymes.
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