Sheikh Atiq-ur Rehman, Safdar Ali, Muhammad Younus Khan, Irfan Ashraf, Muhammad Shoaib Abdullah.
Frequency of HER-2 receptors in patients with breast cancer.
Pak J Surg Jan ;32(3):130-6.

Objective: To determine the frequency of HER-2 receptors in patients with breast cancer. Methods: Th is study was conducted at Department of Surgery, Bahawal Victoria Hospital and BINO Cancer Hospital Bahawalpur from 22-08- 2014 to 21-02-2015. Th is was a cross sectional study. A total of 126 consecutive cases of breast cancer were included in study. A tissue biopsy was sent for immunohistochemical (IHC) studies (HER-2/neu receptors and ER/ PR receptors and detailed histopathological analysis including tumour subtype, histological grade. Patients having only ductal and lobular histopathologic type were included in the study. Name, age, weight, height and age at first live birth noted. Statistical Analysis was done with SPSS 16. Results: 126 patients of breast cancer included in the study were diagnosed on histopathology of tissue sample. All patients were female. Age distribution ranged from 20- 73 years with a Mean±SD of age 44.1±11.2 years. 73 (57.9 %) patients were >41 years. Th e HER-2/neu receptor, ER, PR receptor were found positive in 41.3%, 61.9%, 53.2% of patients respectively. Majority of patients 113 (89.7 %) were found with invasive ductal carcinoma. 45 (35.7 %) patients were obese. In our study HER-2 Receptor status was not significantly associated with age at first live birth of respondents (n=126) and obesity but it was significantly associated with younger age groups (p<0.05) Conclusion: There is a significant correlation between HER-2 receptor and younger age group. HER-2/neu receptor status should be checked in all breast cancer along with estrogen and progesterone receptor especially in young people.

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