Zeeshan Hyder, Ghansham, Sagheer H Shah, Syed Osama Zohaib Ullah.
To compare the frequency of healed wound in patients with hemorrhoids after Milligan-Morgan haemorrhoidectomy given 0.2% topical glyceryl trinitrate (GTN) versus placebo.
Pak J Surg Jan ;32(4):234-8.

Objective: To compare the frequency of healed wound in patients with hemorrhoids after Milligan-Morgan haemorrhoidectomy given 0.2% topical glyceryl trinitrate (GTN) versus placebo Setting and duration: Department of surgery ward 26, Jinnah Postgraduate Medical Centre, Karachi. It was carried out in 6 months from feb 2015 to aug 2015. Study Design: Randomized Clinical Trial Methodology: there was total of 124 patients with hemorrhoids were included in this study. Patients were randomly allocated into two groups. Sixty two patients were in group A and treated with 0.2% GTN ointment and 62 were in group B and treated with placebo ointment (petroleum Jelly). A proforma was used to document findings, it included demographic information like patient’s age, gender, duration of hemorrhoids hospital registration No, group of patient and wound healing at 2 weeks post operatively. Results: Rate of wound infection was significantly high in group B than group A (67.7% vs. 16.1%; p=0.0005). Conclusion: GTN ointment enhances the healing of post hemorrhoidectomy wounds without significant side effects.

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