Anum Naz, Taha Junaid, Muhammad Saad Usmani, Muhammad Khurram Zia.
Estimation of CRP levels on a measure of stress response after Laparoscopic and open cholecystectomy.
Pak J Surg Jan ;33(1):4-8.

Objective: To determine CRP levels on a measure of stress response after Laparoscopic and open cholecystectomy. Method: A cross-sectional observational study was conducted at Abbasi Shaheed hospital, Karachi from June 2015 to August 2015. Patients admitting with fever, abdominal pain, vomiting, nausea, anorexia diagnosed as case of cholelithiasis were selected. Laboratory investigations, ultrasonography and chest radiography were done on admission for cholecystectomy to confirm the diagnosis and avoid negative exploration of abdomen. Post-operatively the CRP levels were sent. Result: Among 100 patients, who were found to be candidates for open and laparoscopic cholecystectomy, were admitted. The average age of patients with Standard deviation was 36.11 ±8.009 years. There were 41 males and 59 females. The two groups were then compared at 4 hours, 8 and 24 hours. The mean CRP after 4 hours after laparoscopic cholecystectomy was 7.84 ±2.99; however after open cholecystectomy was 11.24± 1.47. The mean CRP after 8 hours after LC was 14.78 ±6.37; however after Open cholecystectomy was 20.54 ±3.44. The mean CRP after 24 hours for LC was 24.42 ±9.42; however after open cholecystectomy was 35.28 ±6.34. Both of procedures values were compared with t test applied which revealed statistically significant value p- 0.000. Post-operatively the CRP levels of both the patients were compared with statistically significant value found i.e; p-value 0.000. No postoperative complication and mortality was found in the present study. Conclusion: CRP is a useful marker in determining stress response in patients with open cholecystectomy and laparoscopic cholecystectomy.

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