Uzma Saeed, Naveed Muzhar.
Correlating Serum Beta hCG Levels with Transvaginal Sonographic Features of Ectopic Pregnancy.
J Rawal Med Coll Jan ;21(1):64-7.

Background: To correlate Beta Hcg Levels with transvaginal sonographic features of ectopic pregnancy Methods: In this prospective study 204 patients with confirmed diagnosis of ectopic pregnancy (EP), by both trasnvaginal sonography (TVS) and histopathology were included . Results of TVS and serum ?HCG levels were obtained. Other variables were age, gestational age, size, site and volume of EP, fetal cardiac activity and presence or absence of pelvic ascites. Results: Sensitivity and specificity of TVS for detection of EP was 98% and 87.5% respectively. The values of median and range for the age, gestational age, ?HCG and volume of EP were 29 (17-43) years, 5(4-6) weeks, 3248.5 (14-53048) IU/L, 8648.36 (268- 80491) mm3 respectively. Most common site of EP was adnexa (93.6%) and most common side was right (52%). Fetal cardiac activity was evident in 4.4% cases and pelvic ascites was present in 64.7% cases. There was no significant difference between two ?HCG groups (<2000, >2000) in terms of qualitative and quantitative variables except the volume of EP which was significantly different among groups (p value <0.0001). Conclusion: Serum ?HCG level alone cannot diagnose or exclude EP confidently and it is significantly correlated with the size of EP. The combination of serum ?HCG and TVS provide highly accurate diagnostic information.

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