Namra Naeem, Noreen Akhtar, Usman Hassan, Mudassar Hussain, Asif Loya, Sajid Mushtaq.
Clinicopathological Study of Solid Pseudopapillary Tumor of Pancreas.
Pak Armed Forces Med J Jan ;67(5):803-7.

Objective: To study the morphological and immunohistochemical features of solid pseudopapillary tumor of pancreas. Study Design: Retrospective study. Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre from Jun 2016 to Mar 2017. Material and Methods: Sixty-four patients (n=64) including 61 females and 3 males with pathological diagnosis of solid pseudopapillary tumor were selected from archives of Shaukat Khanum Memorial Cancer Hospital and Research Center for the period of 2000-2017. for the sample selected, their morphological features and immunohistochemical profile were reviewed and analyzed. the morphological features are considered as gold standard for the diagnosis. Results: the mean age was 33 years (range 8-50 years). Immunohistochemical stains were performed on formalin fixed paraffin embedded section of 55 cases. Pancytokeratin was performed on 8 cases, out of which only 2 cases showed positivity. CD10 was performed on 14 cases, out of which only 12 cases showed positivity. Neuron specific enolase (NSE), CD56, vimentin, progesterone receptor (PR) and ? catenin were performed on 8,5,3,13 and 16 cases respectively and showed positivity in majority of cases. Neuroendocrine markers (chromogranin and synaptophysin) were performed on 25 and 6 cases, from which it showed weak positivity in 3 cases. CD99 was performed on 19 cases and showed characteristic dot like staining. Conclusion: among the immunohistochemical stains, CD99 had a specific dot like staining pattern and was used as a first line marker in diagnosis.

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