Tayaba Javed, Rozina Jaffer, Munazza Hassan.
A Brief Review of ER, PR Expression in Breast Carcinoma in Pakistani Women, a Few Neighboring Countries and Certain Muslim Races.
J Fatima Jinnah Med Uni Jan ;11(1):61-4.

Objective: The main purpose of this study was to focus on the ER, PR expression which was carried out in 72 histologically diagnosed cases of breast carcinoma. Material and Methods: This descriptive study was carried in Department of Pathology, Services Institute of Medical Sciences, Lahore conducted on 72 cases of histological diagnosed cases of breast carcinoma. The sample size was calculated using 10% expected prevalence of invasive breast carcinoma at 95% confidence interval and 10% level of precision. Sample technique was convenient sampling. Breast carcinoma is a major challenge affecting one in every eighth women and a major of cause in developing as well as developed countries. It is a heterogeneous disease (genetically and clinically) affecting those with a genetic susceptibility and positive family history. Universally, iimmunohistochemistry method is used to study hormone receptors in breast carcinoma. This method is cost effective, easier to interpret and translate. ER, PR expression was studied by IHC. The receptors were correlated with grades and were compared with clinic-morphological parameters. Scars Bloomfield Richardson grading system was used for grading. Results: Data was analyzed and ER+PR+ status was found in 28/72 cases with a percentage of 38.8%.In ER- PRthere were 44 cases with a percentage 61.1%. Furthermore, 09 cases in Grade-I were ER+ PR+ , 36 cases in Grade-II showed negative ER PR status and 11 cases with positive ER PR status. All 21 cases in Grade-III were negative. Conclusion: This study concluded that in breast carcinoma there are more ER PR negative tumors as compared to ER PR positive tumors.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com