Farhan Majeed, Sehrish Majeed, Salman Majeed, Maham Farhan, Muahammad Qasim.
Improvement in Bone Mineral Density after Vitamin D Supplementation in Post-Menopausal Osteoporotic Women.
J Fatima Jinnah Med Uni Jan ;11(1):48-51.

Background: Osteoporosis is a common disorder in women having menopause. It is a skeletal disorder with low bone mass, increased bone turnover, and with structural defects resulted in higher risk of fractures. Bones have a number of essential components, Vitamin D is one of them and its deficiency is common in osteoporotic patients. Objective: The objective of this study was to determine mean increment in bone mineral density in terms of increment in T-score after giving Vitamin D in post-menopausal osteoporotic woman. Methods: This six months Quasi-experimental study was conducted in the Department of Orthopedics, Lahore General Hospital. Total, 60 women with post-menopausal osteoporosis with Vitamin D deficiency were included in this study. Bone mineral density (BMD) was determined in all these women at baseline and at 16th week, after vitamin D supplementation, using ultrasound impedance Dual Energy X-ray Absorptiometry (DEXA) across the calcaneum, at lumbar spine and femur neck, calculated by a computeraided device. T-score was used to describe BMD. T-score ?-2.5 represents low BMD/osteoporosis as defined by WHO. The data was entered and analyzed in SPSS version 20. Results: The mean age of the patients was 58±9.36 years. There were 20 (33.3%) obese and rest of 40(66.7%) were non obese. A total of 35 (58.3%) patients had <2 years duration of symptoms, 11(18.3%) had 2-5 years of duration and 14(23.3%) had >5 years of duration of symptoms. The mean T-score pretreatment was -3.20±0.390 and after 6 months was -0.47±1.48. On applying paired sample t-test significant improvement in T-score was reported (p <0.001) irrespective of age, BMI and duration of Symptoms. Conclusion: Vitamin D supplementation (200,000 IU) in post-menopausal osteoporotic women after every 15 days until 4 months is an effective way to treat its deficiency as evident by improved BMD.

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