Saira Bilal, Basma Khan, Nighat H Khan.
Magnetic Resonance Spectroscopy as a Valuable Tool to Differentiate Benign from Malignant Lesions in the Brain.
J Fatima Jinnah Med Uni Jan ;11(2):18-21.

Background: To make a distinction between benign and malignant space occupying lesions in the brain with the help of magnetic resonance spectroscopy. Methods: This six months descriptive cross-sectional study was carried out in Radiology Department of PGMI/AMC/LGH and FJMU/SGRH Lahore. A total of 150 patients who were referred to the respective Radiology Departments of LGH and SGRH for Magnetic Resonance Spectroscopy of intracranial space occupying lesion seen on MRI brain scan were recruited for this study. Correlation was made with histopathology done in the respective hospital?s pathology departments as well as from outside laboratories and was taken as the gold standard. Results: This study showed that Magnetic Resonance Spectroscopy added to MRI brain scan with tumefactive ambiguous lesions improved the diagnostic accuracy. In this study, 90% of the patients were reported as malignant on MRI brain. Out of these 88.8% were reported malignant on magnetic resonance spectroscopy and 80% were malignant on histopathology. Conclusions: Magnetic resonance spectroscopy is a helpful tool in differentiating malignant from benign lesions in the brain in ambiguous cases.

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