Hamama tul Bushra Khaar, Muhammad Umar, Muhammad Khurram, Masood Khan, Zahid Minhas, Fayaz Goraya, Saima Javed, Abdul Shakoor, Amir Rizwan, Muhammad Tahsin Hashmi.
Endoscopic and Histopathological Evaluation of 306 Dyspeptic Patients.
Pak J Gastroenterol Jan ;17(1):4-7.

In this prospective, observational study, done at DHQ Teaching Hospital, Rawalpindi and Shifa Gastroenterology and Liver Clinic from July 2000 to July 2002, 306 patients with dyspeptic symptoms underwent upper GI endoscopy and gastric biopsies employing standard protocols. Duodenal biopsy was also performed when appropriate. An experienced pathologist did histopathological examination of biopsies. Data regarding endoscopic findings/diagnosis, biopsy reports, and patient characteristics (i.e., age and sex) were noted. This data was converted into variables, which were analyzed using statistical program SPSS version 8. Of the 306 dyspeptic patients who underwent endoscopy and biopsy, 67% (n=205) were male and 33% (n=101) female. Mean patient age was 36.37 ± 12.69 years. Antral gastritis was commonest endoscopic finding i.e., 86.9% (n=266) patients. Other notable endoscopic findings were duodenitis, gastric growth/polyps, and duodenal growth. Histopathologically gastritis (mild, moderate, marked, and active) was observed in 94.1% (n=288) patients. Adenocarcinoma, hyperplastic gastric polyps, non-specific duodenitis and duodenal villous atrophy were other histopathological diagnosis. Helicobacter pylori was observed in biopsies from 81% (n=248) subjects. It is concluded that majority of patients with dyspepsia have endoscopic and histopathological evidence of gastritis. Helicobacter pylori infection is also common in these patients.

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