Qaisar A, Jatala UW, Fareed MA, Yazdanie N.
Measurement of Residual Monomer in Autopolymerized Acrylic Resins By High Pressure Liquid Chromatography.
Biomedica Jan ;33(3):211-5.

Background & Objective: Autopolymerized acrylic denture base resins are widely used in dentistry due to many desirable properties. However, it is possible to have residual monomer leakage from these resins even after setting is completed. Therefore, the objective of present study was to measure the amount of residual monomer leached from two commercial acrylic polymers by High Pressure Liquid Chromatography (HPLC) at different time intervals. Methods: Two Autopolymerized denture base polymers, pink-veined (Universal Dental, Meadway, England) and clear acrylic (Universal Dental, Meadway, England) were selected to measure the residual monomer concentration by HPLC (Waters System, Woldbronn, USA). Twelve disc-shaped specimens (5 mm × 25 mm) were prepared for each group (pink) and clear acrylic) and stored in distilled water sealed glass container at 37?C at time intervals of 1, 2, 6, 12, 24 hours and 1 week. Mean concentration was recorded in parts per million (ppm) as final monomer concentration of the specimen. The data was analyzed by ANOVA and t-test to determine the differences in monomer released at different time intervals and p value < 0.05 was considered significant. Results: HPLC showed statistically significant differences among two groups (P < 0.05) in the amount of eluted monomer There were significant differences at one hour (T 1) (p = 0.001), at two hours (T2) (p = 0.011) and insignificant difference (p = 0.606) was observed at the six hours (T3 ) interval in the residual monomer release in two groups. However, at 12 hours (T4) and one week (T6) intervals, there was a gradual decrease of residual monomer release in both groups. Conclusion: There was significant (P < 0.05) amount of residual monomer released from both pinkveined and clear Autopolymerized resins at different time intervals.

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