Shazia Naseeb, Khadija Bano, Razia Korejo.
Maternal and Perinatal Outcome of Preeclampsia and Eclampsia Treated with Magnesium Sulphate.
J Surg Pak Jan ;20(4):133-7.

Objective: To determine the maternal and perinatal outcome of pre-eclampsia and eclampsia treated with magnesium sulphate. Study design: Interventional study. Place & Duration of study: Department of Obstetrics and Gynecology Unit-I, Jinnah Postgraduate Medical Centre Karachi, from May 2012 to April 2014. Methodology: All patients admitted with pre-eclampsia and eclampsia were included. After taking detailed history and clinical examination they were treated with magnesium sulphate (MgSO4). Patients were monitored for recurrent fits, side effects of MgSO4, and causes of discontinuation of treatment. Maternal outcome in terms of mode of delivery, number of maternal deaths and perinatal outcome in terms of perinatal death and APGAR scores were recorded. Results: The study was conducted on 50 pre-eclamptic patients (Group-I) and 100 eclamptic patients (Group II). Mean age of patient in group-I was 26.94 ±5.5 year and in Group-II 24.32±5.8 year. High frequency of eclampsia (n=61, 61%) was found in antepartum cases. Majority of patients (n=79, 52.6%) were primigravidae in both the groups. In group-II five patients had recurrence of fits. There were seven maternal deaths due to eclampsia but none of the deaths was attributed to magnesium sulphate therapy. Overall perinatal mortality was 30.7% (n=46). Conclusions: Recurrence of seizure was seen in only 5% eclamptic women and none in those with severe pre-eclampsia. Magnesium sulphate was found effective in treatment as well prophylaxis of eclampsia.

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