Nazish Iqbal, Muhammad Waqaruddin Sheroze, Abdul Ali Khan.
Froin`s Syndrome due to Spinal Paraganglioma - a Case Report.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;23(03):156-60.

Yellow coloured, i.e. xanthochromic cerebrospinal fluid, with hypercoagulability and high protein content is pathognomic of Froin's syndrome. We present a case of Froin`s syndrome in a patient with spinal paraganglioma. A 55-year-old male patient presented with urinary hesitancy, numbness in lower limbs and difficulty in walking. During spinal anaesthesia, the anaesthetist noticed xanthochromic spinal fluid. Upon magnetic resonance imaging lumbosacral, an intradural focal lesion of abnormal signal intensity extending from T12-L1 vertebral level was seen. Laminectomy with excision of the mass was performed and a fleshy encapsulated mass was excised. Histopathology report showed the specimen to be a neoplastic lesion, and immuno-histochemical studies confirmed the mass to be a paraganglioma. This case emphasizes that in case of Froin`s syndrome, one should think of spinal cord tumours while evaluating the patient. A magnetic resonance imaging of the spine should also be done to look for spinal pathology along with other investigations.

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