Seeba Hussain, Md Raihan, Abhijeet Kumar Jha, Satyaki Ganguly, Kranti Chandan Jaykar, Paritosh Kumar Banerjee.
Comparative evaluation of hydroquinone, tretinoin and mometasone versus glycolic acid versus trichloroacetic acid peel in melasma.
J Pak Assoc Derma Jan ;26(1):31-4.

Objective: Comparative evaluation of 2% hydroquinone, 0.025% tretinoin and 1% mometasone versus glycolic acid and trichloroacetic acid peel alone in melasma. Methods: Seventy five patients were included in the study. Total duration of study was one and a half years. Melasma area severity index (MASI) score of more than 10 were included in the study. The patients were divided into three groups. Group A consisted of 25 patients and were given 2% Hydroquinone, mometasone 1% and 0.025% tretinoin. Group B consisted of 25 patients and underwent glycolic acid peel. Group C consisted of 25 patients and underwent trichloroacetic acid peel. Results: Group A had better response, followed by group B and group C, respectively. Conclusion: Combination of hydroquinone, mometasone and tretinoin is a good option to treat melasma only when used judiciously along with sunscreen, whereas glycolic acid peels are a safer option with fewer side effects.

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