Ayesha Khan, Nasim Karim, Jahan Ara Ainnuddin.
The Triad of PCOS, Infertility and Metformin.
J Bahria Uni Med Dental Coll Jan ;9(1):67-71.

ABSTRACT: Polycystic ovarian syndrome (PCOS) is now considered as a complicated disease of endocrine system. It is found in 5- 10% of women of fertile age group. It was initially considered as a reproductive disorder in women. Studies in recent past have documented that PCOS is a metabolic syndrome and is influenced by genetic and environmental factors. It is also transferred genetically, an autosomal dominant trait with variable penetrance. Since role of insulin resistance has been identified as a main culprit in the development of PCOS therefore use of insulin sensitizers to treat PCOS seems logical. Insulin sensitizer such as metformin is a therapeutic option that targets not only insulin resistance present in this syndrome but several other aspects especially reproductive abnormalities such as infertility, which is a major problem of concern for women of reproductive age. This review attempts to cover the use of metformin in PCOS infertile women.

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