Madeeha Gulzar, Ali Sabir, Muhammad Afzal Hamdani, Asma Saadia.
Macrophage Activation Syndrome Associated with Adult Onset Still`s Disease.
J Ayub Med Coll Abottabad Jan ;30(2):289-92.

Macrophage activation syndrome (MAS) is a potentially lethal complication of chronic rheumatological conditions like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still?s disease (AOSD). It is a multisystem inflammatory syndrome caused by immense cytokine release from activated lymphocytes and macrophages. We give an account of the incidence of a twenty years old Asian girl suffering from non-remitting fever and an evanescent rash for last ten weeks. Physical examination and laboratory work-up suggested high grade fever, pancytopenia, hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia and impaired liver function. Bone marrow biopsy was also done. It showed active hemophagocytosis. She was diagnosed as a case of Macrophage Activation Syndrome associated with Adult Onset Still?s disease. She was treated with high dose steroids and cyclosporine and recovered completely.

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