Zahra Naz, Alia Batool, Abdul Rauf, Hajra Azhar, Junaid Akhtar, Fariha Fayyaz.
High Resistance In Uropathogens Isolated From Children At Pakistani Hospital.
J Uni Med Dent Coll Jan ;9(1):26-32.

Urinary tract infection is one of the most important clinical infections in the world. Due to empirical therapy, antibiotic resistance pattern has been altered in the causative microbes of urinary tract infection in childhood. The objective of this study was to find out causative agents of urinary tract infection in children and their antimicrobial profile. A total of 1370 urine samples were collected and identified by standard microbiological techniques. Antimicrobial susceptibility of isolates was performed according to CLSI 2012 guidelines. Significant bacterial count was found in 8.32% children. Most common isolated pathogens were Escherichia coli (60.5%) and Klebsiella pneumoniae (26.3%). Pathogens were resistant to cefixime (83%), ceftriaxone (81%) and amoxicillin-clavulanic acid (69%). Acinetobacter baumannii were found most resistant. Meropenem, amikacin and piperacillin-tazobactam were most effective. It is concluded that multidrug resistant organisms causing UTI in children in our locality. It is suggested that local surveillance studies should be done continuously to screen antimicrobial resistance.

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