Asma Parvez, Kamran Khan, Jawaria Bibi.
Does Diclofenac Sodium Provide Better Preemptive Analgesia than Ketoprofen in Impacted Third Molar Surgery? a Randomized Controlled Trial.
J Islamic Int Med Coll Jan ;13(3):122-7.

Objective: To compare ketoprofen and diclofenac sodium as a preemptive analgesic in impacted third molar surgery in terms of mean pain score and mean time of first analgesic postoperatively. Study Design: Double blinded, parallel arm Randomized Controlled Trial (RCT). Place and Duration of Study: The study was conducted from 15th April, 2016 to 5th November, 2016 at Oral and Maxillofacial Surgery Department of Islamic International Dental Hospital, Riphah International University. Materials and Methods: Eighty patients requiring surgical extraction of impacted mandibular third molar were selected by using randomized sampling technique. These patients were randomly assigned two groups using lottery method, resulting in sample size of 40 in each group. Preoperatively diclofenac sodium was administered intramuscularly in group A and ketoprofen in group B using double blinded technique. Pain score was measured 3 hours after surgery using visual analogue scale (VAS) and the time of first analgesic consumption post-operatively was recorded in hours. Statistical Package for Social sciences (SPSS version 16) was used for data analysis and Independent sample T test was applied to compare mean pain score and time of first rescue analgesics between two groups with 0.05 as a level of significance. Results: Results showed that mean pain score was less in Ketoprofen group (3.42+1.08) than diclofenac sodium group (4.02+1.20) with significant p-value of 0.02. Time interval for first analgesic post-operatively was also measured in hours. Results were highly significant revealing prolonged analgesic effect in Ketoprofen group with p-value of 0.007. Conclusion: Preemptive Ketoprofen provides better and prolonged pain control as compared to Diclofenac Sodium in impacted third molar surgery.

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