Rukhsana Munawar, Adnan Jehangir, Akbar Waheed.
Comparing Hepatoprotective Effects of Aqueous Extract of Cassia Fistula (Amaltas) Leaves and Silymarin.
J Islamic Int Med Coll Jan ;13(3):137-40.

Objective: To compare the hepatoprotective effects of aqueous extract of Cassia fistula leaves and Silymarin on Acetaminophen induced hepatotoxicity. Design of Study: An experimental study in mice. Place and Duration of Study: The study was conducted in the department of Pharmacology and Therapeutics, Multidisciplinary research laboratory of Islamic International Medical College, Riphah International University. The duration of study was from 16 Mar, 2016 to 16 Mar, 2017. Materials and Methods: In present study simple random sampling was done by Balloting method and sixty adult Balb/c Albino mice were divided in four groups having 15 mice each. Mice in control group A were given normal diet and fresh water. Mice in experimental group B (positive control) were given Acetaminophenat dose of 100mg/kg/day orally for six weeks. Mice in experimental group C were treated with Acetaminophen(100mg/Kg) with concurrent 400mg/Kg body weight of Cassia fistula (Aqueous extract) orally for six weeks once daily while in experimental group D mice received 750 mg/kg body weight of Silymarin orally in form of aqueous suspension in 2% Cremophor1E for 6 weeks once daily concurrently treated with Acetaminophen(100mg/Kg).The cardiac puncture was done after six weeks and 2.5cc blood was collected from each mice for assessment of biochemical markers including Serum Alanine Aminotransferase (ALT) and Serum Aspartate Aminotransferase (AST). Results: The mean value of serum ALT level was 130.4.30 ±42.90 in Group B as compared to control Group having mean value of ALT 37.30 ± 8.32. The mean value of ALT was 62.22± 19.27 and 53.90± 25.06 in Group C and in Group D respectively. In Group B mean value of serum level of AST was 134.3± 15.56 as compared to control Group A having mean value of AST31.40± 10.05.The mean value of AST in Group C and Group D were 66.40±20.50 and 44.67± 20.37 respectively. Conclusion: The Silymarin is more beneficial than aqueous extract of Cassia fistula leaves in ameliorating hepatotoxic effects of Acetaminophen

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