Riffat Raja, Maria Khaliq, Sana Wasim, Sidra Nadeem, Sadaf Arooj, Khoala Riaz.
Diagnostic accuracy of MRI in detecting parametrial invasion in carcinoma cervix.
Pak J Med Res Jan ;58(1):3-6.

Objective: To evaluate the accuracy of MRI in detecting parametrial invasion in carcinoma of cervix keeping histopathological findings as gold standard. Study design, settings and duration: A cross sectional study was conducted in Radiology Department, Holy Family Hospital, Rawalpindi from November 2017 to October 2018. Patients and Methods: One twenty eight patients with biopsy proven cervical cancer were enrolled. Magnetic resonance imaging of study patients was performed on 1.5 Tesla GE MRI machine using pelvic array coil for pelvic scan. Positive patients were then sent to gynecology department for hysterectomy after which the specimens were sent for histopathological analysis. All the specimens were reviewed by experienced histopathologist and were labelled as positive and negative for cervical parametrial invasion. Results: Mean age of study patients (n=128) was 49.9 years ±6.7 standard deviation, with a range of 41-69 years. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of MRI in detecting parametrial invasion in carcinoma of cervix was found to be 84.5%, 84.2%, 86.9%, 81.3% and 84.3% respectively. Conclusion: MRI is a reliable and non-invasive diagnostic imaging modality that allows the detection of parametrial invasion in patients of cervical cancer with high sensitivity, specificity and accuracy.

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