Muhammad Rafiq, Laure Pain, Naseem Ahmed.
Effect of inflammation and anesthesia on brain-derived neurotrophic factor and cognition.
Anesth Pain Intens Care Jan ;23(3):318-22.

Background: Some studies have evidenced the effect of inflammation and anesthetics on Brain Derived Neurotrophic Factor (BDNF) but there is still no data regarding the effect of inflammation and anesthesia alone or in combination of inflammation and anesthesia on BDNF protein in rats? brain. Objectives: To examine effect of lipopolysaccharides (LPS) alone or combined with propofol anesthesia at 3rd of injection on cortical and hippocampal BDNF. Methodology: Male rats in four groups were treated with Intralipid® control, propofol anesthesia (120 mg/kg), LPS (1 mg/kg) and combined propofol with LPS respectively. The brains were removed and brain homogenates were prepared from hippocampus and cortex tissues. The amount of BDNF protein was assessed using ELISA on the brain supernatants. Results: BDNF protein was increased when subjects were injected with propofol anesthesia alone (about 30%) or to LPS injection (about 400%) in both cortex and hippocampus samples. When anesthesia was injected combined with LPS, BDNF protein was decreased in both cortex and hippocampus samples (p < 0.01). Conclusion: Our data evidenced the long term effect of propofol and LPS in increasing BDNF and propofol combined with LPS decreases BDNF protein in hippocampus and cortex.

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