Huma Ali, Amber Nawab, Najaf Farooq, Irfan Ashraf, Maria Sodagar, Anam Tariq, Ghazala Raza Naqvi.
Celecoxib as an Effective Cox-2 Inhibitor for Rheumatologic Disorders: Efficacy and Safety Concerns.
Ann Jinnah Sindh Med Uni Jan ;4(1):51-6.
Background: NSAIDs are among the most commonly used anti-inflammatory drugs by patients, the mechanism of action of NSAIDs is quite clear. It inhibits the cyclooxygenase mechanism resulting in decreased production of arachidonic acid as the COX-action induces its production. Objective: To elucidate and compare celecoxib as an effective Cox-2 inhibitor for rheumatologic disorders alongwith efficacy and safety concerns. Methodology: A systemic review was carried out and literature survey was done. In this regard, more than 50 articles were surveyed for related terms. Results: The review concluded that besides the inhibition produced by NSAIDs on COX-1, some adverse effects arise which include mainly gastric discomfort. NSAIDs are recommended to be given along with any Proton Pump Inhibitor (omeprazole or esomeprazole). Non-selective NSAIDs which inhibit COX-2 action have less adverse effects on gastrointestinal system. Celecoxib is used for the treatment of rheumatologic disorders and is a safe NSAID in comparison to COX-1 inhibitors. Conclusion: Celecoxib inhibits the release of glycosaminoglycan and stimulates the synthesis of proteoglycan in the body. Researchers have proved that there is no difference in the activity of traditional NSAIDs and Celecoxib, although the statement is debatable. Key words: Celecoxib, NSAIDs, COX-1, COX-2, Rheumatologic disorders
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