Shahadat Hussain, Saulat Siddique, Qazi Abdul Saboor.
Heart Rate Variability in Early Phase of Acute Myocardial Infarction and Convalescence.
J Coll Physicians Surg Pak Jan ;13(2):67-9.

Objective: This study was done to evaluate the degree of change in autonomic activity, manifested as heart rate variability (HRV), from acute phase of MI to convalescent period of AMI. Design: Single center, observational prospective study. Place and Duration of Study: Department of Cardiology, Shaikh Zayed Hospital, Lahore. The study was completed in one year from June 2000 to July 2001. Subjects and Methods: Thirty consecutive patients presenting within 24 hours of an ST segment elevation AMI with or without thrombolysis were included. First 24 hour Holter recording was done within 24-36 hours after AMI and the second was done before discharge. Results: The mean hospital stay was 7.07 ± 2.56 days. Mean duration between the two recordings was 5.47 ± 2.36 days. The mean standard deviation of normal sinus interval (SDNN) was 65.07 ± 25.11msec & 63-97 ± 23.38msec; mean standard deviation of averaged sinus beats for 5 minutes segments of entire recording (SDANN) was 51.27 ± 18.57msec and 55.83 ± 19.65msec and mean SDDN index was 34.57 ± 17.15msec and 30.57 ± 14.89msec during early phase of acute MI & pre-discharge recordings respectively. There was no statistically significant difference in HRV between early phase of acute myocardial infarction and of pre-discharge recordings. Conclusion: HRV may be monitored for risk stratification at any time post AMI prior to discharge.

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