Neelam Halimi, Munir Ahmad, Hafiz Muhammad Waqas, Muhammad Basit.
Comparison of ondansetron and dexamethasone combination with odensetron in preventing postoperative nausea and vomiting in patients of laparoscopic cholecystectomy.
Pak J Surg Jan ;35(1):16-20.

Objective: To compare the efficacy of ondansetron and dexamethasone combination with ondansetron alone in preventing post-operative nausea and vomiting in patients of laparoscopic cholecystectomy. Material and Methods: This randomized controlled trial was conducted in Department of Anaesthesia and Surgery, Khyber Teaching Hospital, Peshawar from January, 2017 to June, 2018. 208 patients fulfi lling the criteria were hospitalized for laparoscopic cholecystectomy. 104 patients were allocated in ondansetron and dexamethasone combination ( group A ) while 104 patients in ondansetron only ( group B ) by simple random technique. The incidence of nausea and vomiting was recorded for first 24 hours post-operatively. Data were compiled and analyzed with SPSS 20. Chi-square test was applied to compare efficacy in both groups, taken P < 0.05 as significant. Result: Mean age in Group-A was 30±10.21 years and in Group-B was 3±9.27 years. Male to female ratio in Group-A was 3.2:6.8 and in Group-B was 3:7. Ondansetron and dexamethasone combination was effective in 90% patients where as Ondansetron alone was effective in 68% patients which was statistically significant with P-value=0.0001. Conclusion: Combination of ondansetron and dexamethasone is more effective than ondansetron alone in preventing post-operative nausea and vomiting in patients of laparoscopic cholecystectomy and it?s use should be encouraged in routine cases.

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