Nakhshab Choudhry, Sana Sarmad, Noor-ul Ain Waheed, Aamir Jamal Gondal.
Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma..
Pak J Med Sci Jan ;35(1):252-6.

To estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects. In this observational study, biopsy diagnosed oral squamous cell carcinoma patients (n= 38) were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls (n= 38) were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA. Serum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group (p < 0.01). The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml. MMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com