Saba Aneeqa, Faiza Kazi, Mumtaz Ahmed, Irum Sohail, Fatima Tul Zahra, Masood A Khan.
The frequency of uterine pathological changes in patients presenting with abnormal uterine bleeding between 45 to 65 years of age in hysterectomy specimens.
Pak J Pathol Jan ;29(2):30-3.

Objective: To determine the frequency of various uterine pathological changes in hysterectomy specimens with clinical history of abnormal uterine bleeding. Study Design: Cross sectional study. Place and Duration of study: This study was done in the Department of Histopathology, Foundation University Medical College and Fauji Foundation Hospital Islamabad from 2nd Sep, 2016 to 2nd Mar 2017. Material and Methods: 600 cases of hysterectomy specimens were included in the study in patients presented with abnormal uterine bleeding. The age ranges from 45 to 65 years.  After fixation of specimens, these were grossed according to standard protocol followed by processing and paraffin embedding. Slides were manually stained by a lab technician. The microscopic examination was carried by the trainee along with two consultants of histopathology. Results: A total of 600 patients were included in the study. Mean age (years) of the patients was 50.91+5.76. Frequency of various pathologies in hysterectomy specimens was analyzed which included leiomyoma 189 (31.5%), adenomyosis 172 (28.7%), endometrial polyp 135 (22.5%), endometrial hyperplasia 48 (8.0), disordered proliferative endometrium 31 (5.2) followed by endometrioid carcinoma 25 (4.2). Conclusion: The study concludes that there were various frequencies of uterine pathologies in hysterectomy specimens. Most frequent causes of prolonged menorrhagia were leiomyoma, adenomyosis and endometrial polyp in the study. Key Words: Abnormal uterine bleeding, Adenomyosis, Endometrial carcinoma and endometrial polyps.

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