Salma, Sadia Ghousia Baig, Muhammad Mohtasheem-ul Hasan, Salman Ahmed, Syeda Anum Fatima.
The Effect of Phaseolus Vulgaris L. Fixed Oil on the Behavioural Activity of Swiss Albino Mice.
RADS J Pharm Pharmaceut Sci Jan ;6(1):76-82.
Background:Phaseolus vulgaris commonly known as kidney bean has been studied previously for pharmacological activities like antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore objective of the present study is to investigate the behavioural activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark , stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally, 30 minutes prior to the performance of tests. In hole board test PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results:In light and dark test PVFO in both doses decreased the time spent in light compartment (p≤0.01). In open field test number of peripheral lines crossed were decreased (p≤0.05) whereas in stationary rod test no effect was observed by any dose of PVFO. Conclusion:Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose dependent sedative hypnotic effect
PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com