Mohammad Ishaque Mujeeb, Piriha Abbasi, Muhammad Amjad Chishti.
Comparative study of Effectiveness and Safety of Herbal Compound Medicine (Constinil) and Allopathic Medicine (Sodium Picosulfate) in Managing Constipation..
RADS J Pharm Pharmaceut Sci Jan ;6(1):67-75.

Background:This present study was conducted to observe the effectiveness and safety of the herbal compound medicine (constinil) and allopathic medicine (sodium picosulfate) in managing the constipation. The functional constipation is a condition which can be described by evacuation of small quantity of feces, may be irregular, infrequent evacuation, hard and forceful pass stool, may defecation occur off/on pattern, delay in defecation once after 48-72 hours. Methods: It was comparative case control study conduct on 110 from Oct-2014 to May-2015 at Hyderabad and Sehwan Sharif, Sindh. Patients only male gender (age between 20-50 years) with clinical diagnosis of functional constipation. Analysis was done by SPSS v20. Results: this study show significant difference in post-treatment of between both groups (test and control group), signs and symptoms and duration of constipation. majority n=56, (91%) belong to hard stool, & feeling of evacuation complaints, n=14 (25%)  out of n=56 belong test group and n=42 (75%) belong to control group P 0.014. Conclusion: Hence it is concluded constipation manage with herbal formulated capsule (constinil) is safer and effective.  

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