Muhammad Osama Alam, Hina Rehman, Amna Qadeer, Hira Munir, Aqib Zahoor, Kashifa Khanum, Khan Usmanghani.
HPLC Determination of Parthenolide in Migraine Orally Dispersible Tablets.
RADS J Pharm Pharmaceut Sci Jan ;6(1):49-52.

Background: The Herb Tanacetum parthenium (feverfew) commercially used for the treatment of migrainedue to the presence of parthenolide. It contains sesquiterpene lactone which is the main active compound of this plant. Since ancient times, the herb has been known for asthma, rheumatism and mainly for migraine with anti-inflammatory effects.  Methodology:In this study, oral dispersible tablets consisting ofTanacetum parthenium and vitamin B2 were prepared by direct compression method. Anhydrous dextrose, Rasberry flavor, Aerosil 200, Magnesuim sterate and Stevia and Sucralose were used as excipients. Samples were analysed by using RP18 column (150 x 4.6 mm id, 5 micron particle size) and having Mixture of Acetonitrile with water 55:45 as a mobile phase. Flow rate were 1.0 ml/min and volume of injection were 20┬ÁL on 210 Wavelength. Results:The prepared batches of tablets were evaluated for weight variation, hardness, friability.Quantitative determination was evaluated via an HPLC method for standard verses tablets. Parthenolide was found 0.365 mg/tablet via an HPLC method. The results confirmed the authenticity of the manufactured tablet with the labelled indication. Conclusion: The active biomarker Parthenolide has quantify with the help of peak by HPLC and authenticate the presence of active in the dispersible oral tablets as compare to the standard.

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