Saira Bano, Hina Rehman, Faheem Akhtar, Amna Iqbal, Kashifa Khanum, Khan Usmanghani.
Comparative Acute Oral Toxicity study of Cartinovex Plus Verses Anti-arthritis Devil's Claw in Mice.
RADS J Pharm Pharmaceut Sci Jan ;6(1):02-6.
Background: Devil's Claw (Harpagophytum procumbens) is herb which is suggested for the management of arthritis as a home remedy. Glucosamine is a another naturally occurring aminomonosaccharide present in articular cartilage of joints and synovial fluid. We established an oral tablet with the name of Cartinovex Plus havingglucosamine with HA and Methyl sulfonyl methan for the pain of arthritis and compare with dewil’s claw for toxicity levels Aims and objectives:The study was completed to assess the comparison of acute oral toxicity of the CartiNovex extract with Anti-arthritis Devil’s Claw extract in the NMRI strain of mice. Methodology:This study will provide genuine in-.house generated information reflecting pre-clinical toxicity of CartiNovex Plus and Anti-arthritis Devil’s Claw product, which will increase our confidence in the product and will facilitate the registration process.NMRI mice were obtained from Animal house facility on standard environmental conditions i.e. 25 ± 1 oC, relative humidity (RH) 52 - 61% and 12 h dark / light cycle. Results:No significance results were obtained on physical and behavior changes. Discussion and Conclusion:No mortality and morbidity were observed and no variation in weights were identified on either groups.It was concluded that both the drugs are potentially safe for use.
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