Maria Sultan, Syed Amir Hamza, Muhammad Naeem Khan.
Efficacy of Topical 0.05% Cyclosporine Eye Drops in Children with Severe Vernal Kerato-conjunctivitis(VKC).
Ophthalmol Update Jan ;16(3):808-12.

Objective: This study was conducted to determine the efficacy of topical 0.05% cyclosporine eye drops in children with vernal keratoconjunctivitis not responding to topical corticosteroids, mast cell stabilizer and antihistamine therapy. Methods: Total 62 patients, 48 boys and 14 girls having age less than 16 years, were included in this study. Four-point scale of 0 to 3 was used to score signs and symptoms for all the patients. Topical cyclosporine 0.05% was used by each patient along with artificial tears and follow up was done for 6 months. The data was entered in the performa at day 0 (before treatment initiation) and at 1st, 3rd, and 6th months of treatment. Results: There was a statistically significant decrease (p<0.05) in severity of all signs and symptoms, after having treatment for six months. No serious adverse effect was noted in patients. Conclusion: In children for controlling signs and symptoms of vernal keratoconjunctivitis, topical cyclosporine 0.05% is effective and a safe treatment.

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