Naila Obaid, Asfandyar Asghar, Amna Rizwan, Sumayya Ali Khan, Banaeem.
Incidence of Thyroid Dysfunction & its Naila Obaid Co-relation with Diabetic Retinopathy.
Ophthalmol Update Jan ;16(3):785-8.

Objective: To evaluate the incidence of thyroid dysfunction in patients with Diabetic Retinopathy and see the correlation with stage of diabetic retinopathy. It was a cross sectional descriptive study in the Department of Ophthalmology, Fauji Foundation Hospital, Rawalpindi. Methods: This study was conducted in Department of Ophthalmology, Fauji Foundation Hospital, Rawalpindi, from 1st September 2016 to 30th March 2017. All the cases of Diabetic Retinopathy were included except those who lost follow up. A detailed history with complete ocular was carried out All the patients were investigated for Glycosylated Hemoglobin (HbA1c), total tri-iodo--thyronine (T3), total thyroxine (T4), and thyroid stimulating hormone (TSH). Results: A total number of 82 patients with non-proliferative and proliferative diabetic retinopathy were studied. There were 27 patients of proliferative Diabetic Retinopathy (PDR) (32.9%) and 55 patients of non-proliferative Diabetic Retinopathy (NPDR) (67%). 25 patients out of total 82 patients had deranged thyroid hormone and TSH levels (30.48%). Among these 25 cases, 13 cases had hypothyroidism, 6 cases had hyperthyroidism and 6 had low T3 syndrome (15.8 %, 7.3 % and 7.3 % respectively). Out of total 27 cases of PDR; 8 cases had hypothyroidism, 6 has hyperthyroidism and 2 had low T3 syndrome ( 29.6%, 22.2 % and 7.4% respectively). While in NPDR group, out of total 55 patients 5 had hypothyroidism (9.09%), 4 patients had low T3 syndrome (7.27%) and none of the patients had hyperthyroidism. Conclusion: Thyroid dysfunction is found in significant number of patients with diabetic retinopathy. Thyroid function tests are more deranged in patients with proliferative diabetic retinopathy than non-proliferative diabetic retinopathy. Thyroid dysfunction may be another risk factor for progression of diabetic retinopathy, hence the thyroid screening in type 2 diabetic patients can favor better management of patients and prevent sight threatening complications of diabetic retinopathy.

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