Muhammad Siyar, Khalid Khan, Muhammad Israr, Zarmina Ahmed, Farhan Akram, Muhammad Khalid.
If Hyperuricemia is a threat for Gout & Myocardial Infarction.
Ophthalmol Update Jan ;16(3):777-80.

Background: Hyperuricemia is being blamed for gout and myocardial infarction. Hyperuricemia is common but most of time not associated with gout. There is limited scientific work available even in Western countries other than epidemiological surveys. Classic topaceous Gout is very rare in Pakistan as compared to West. Oligo arthritis when accompanied by hyperuricemia is frequently labeled as gout. This definitely overestimates the incidence of gout. No doubt hyperuricemia is related to gout and ischemic heart disease. A preliminary study is needed at least we should know the prevalence of hyperuricemia in KPK because uric acid precipitates at saturation and is vasculotoxic. Next we should co-relate it with gout and MI. misconception regarding hyperuricemia must be clarified through good literature review before proceeding to genetic studies and fluid examination for crystal examination. It was a cross sectional study` Objective: Epidemiologic study of hyperuricemia in KPK District Mardan and nearby districts with good literature review to prevent over diagnosis of gout. Study Design: Cross sectional Material and Methods: A total of hundred adult patients, both male and female from KPK were selected in random suffering from various medical conditions like DM, hypertension, irrespective of arthritis/non arthritis, for level of serum uric acid level presented to Mardan Medical Complex, a tertiary care hospital. Clinical condition and hyperuricemia was co related. Serum was tested with Microlab300-and Dialab reagent at pathology dept (BKMC) Bacha khan Medical College Mardan Results: In male 12 %and in female16 % of patients showed hyperuricemia. Three male and one female was suffering from gout. Only one male patients showed classical topaceous gout .In Male mean of 5.28mg/dl with standard dev of 1.34 mg/dl was recorded. In female mean uric acid of 4.82 mg/dl with standard dev of 1.22 was recorded. Highest level of 13.5 and 13 in male and female respectively was also noted. Ischemic heart disease was not seen in any of hyperuricemic patients; Conclusion: Hyperuricemia and gout are less prevalent in KPK as compared to West. Classic topaceous gout is also very rare, though definitely present. Genetic studies and joint fluid for microscopy are mandatory to label a patient of arthritis as gout even with hyperuricemia, to avoid over diagnosis of gout. There is no relationship of ischemic heart disease and hyperuricemia in this study.

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