Abdul Rauf, Uzair Ahmad, Shaukat Husaain.
Frequency of Hyperbilirubinemia in acute Appendicitis.
Ophthalmol Update Jan ;16(3):757-60.

Background: Acute appendicitis is one of the most common acute surgical conditions of the abdomen. Recently hyperbilirubinemia has been shown to be associated with acute appendicitis which occurs presumably as a result of bacteremia and endotoxemia and it occurs in both simple and complicated appendicitis i.e appendiceal perforation or gangrene. Objectives: The aim of this study was to determine the frequency of hyperbilirubinemia in acute appendicitis. Material and Methods: This study was conducted at Surgical Department, KhyberTeaching Hospital, Peshawar from January 2014 to January 2015. Study Design was descriptive (cross sectional) with duration of one year in which a total of 185 patients were observed according to WHO formula for sample size calculation by taking proportion of hyperbillirubinemia 77.8%, margin of error 6% and confidence interval 95%. More over consecutive (non probability) sampling technique was used for sample collection. Results: In this study age distribution among 185 patients was analyzed as 42(23%) patients were in age range <20 years, 61(33%) patients were in age range 21-30 years, 41(22%) patients were in age range 31-40 years, 28(15%) patients were in age range 41-50 years and 13(7%) patients were in age range 51-60 years. Mean age was 30 years with SD+/- 2.54 (Table 1). Sixty two (62%) percent patients were male and 38% patients were female. Twenty eight (28%) percent patients had hyperbilirubinemia while 72% patients didn`t had hyperbilirubinemia. Total serum bilirubin (TSB) level among 185 patients was analyzed as 133(72%) patients had total bilirubin level < 1 mg/dl while 52(28%) patients had total bilirubin level > 1 mg/ dl. Mean bilirubin level was 0.7mg/dl with SD +/- 3.46. Conclusion: Hyperbilirubinemia is a statistically significant diagnostic marker for acute appendicitis and the likelihood of perforation.

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