Faisal Ramzan, Sumera Batool, Fahad Basit, Munir Ahmad.
To Compare the Effect of Cyclizine, Prochlorperazine & Ondansetron in inhibiting Postoperative Nausea & Vomiting following Laparoscopic Cholecystectomy.
Ophthalmol Update Jan ;16(3):749-52.

Objective: To determine the efficacy of prochlorperazine, cyclizine and ondansetron in patients following laparoscopic cholecystectomy, in terms of prevention of vomiting and nausea.It was a randomized control trial study: Anaesthesia department of the Nishtar Hospital, Multan, catering all the four surgical units, over a period from January, 2017 to January, 2018. There is a great load of surgical work in this hospital covering a a larger area of South Punjab. Methodology: Total of 324 patients divided into Group P, group O and group C received prochlorperazine (10mg), ondansetron (4mg) and cyclizine (50mg) respectively. Each patient was asked to tell when he/she is feeling nauseous, vomited and used additional antiemetic drugs. Descriptive data was compared by applying ANOVA test and Chi-square or Fischer`s exact test was applied on nominal data. Computer software SPSS version 23 was used to statistically analyze the data. P <=0.05 was taken as significant. Results: Although occurrence of side effects was slightly higher in group-P, but all the groups were not statistically diffrent (p-value 0.581, 0.500 and 0.544 for headache, dizziness and sedation respectively). Nausea and vomiting was observed in 4.6% in group-O patients, 5.5% in group-C patients and 8.3% in group-P patients, difference being statistically insignificant (p=0.500). Conclusion: From the results of this study it could be concluded that all the three drugs i.e. cyclizine, ondansetron and prochlorperazine are equally effective and there is no statistically significant difference in terms of prevention of vomiting and nausea in patients undergoing cholecystectomy through laparoscope.

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