Faisal Ramzan, Sumera Batool, Fahad Basit, Gohar Ali Arshad.
Correlation: Fibroblast Growth Factor 23 & Metabolism of Vitamin D in patients of Long-standing Kidney Disease.
Ophthalmol Update Jan ;16(3):741-4.

Objective: To examine the effects of fibroblast growth factor 23 (FGF-23) and parathyroid hormone on metabolism of vitamin-D in the patients suffering from stage 3A or higher longstanding disease of kidney.It was aA cross sectional observational study in Medical Unit of Nishtar Hospital Multan between January 25, 2018 and February 25, 2018 Methodology: A total of 40 patients were included in this study. patients with stage 3A of higher longstanding kidney disease were included. Age, body mass index (BMI), rate of glomerular filtration, serum levels of FGF-23, parathormone, creatinine, phosphate, calcium, 25-hydroxycholecalciferol(25-hydoxyvitamin-D); 1 alpha, 25-dihydroxyvitamin D3 and Dihydroxycholecalciferol(24,25-dihydroxyvitamin-D) of forty patients were noted on a preformed performa by the researcher himself. Means of all the factors were calculated, univariateas well as multivariate analysis of variance of the factors against FGF-23 levels and parathormone level. P-value <=0.05 was considered of statistical significance for every factor. Results: On univariate analyses of variance, there was a positive association ofFGF-23 with parathyroid hormone levels (p=0.011) as well as Dihydroxy-cholecalciferollevel (p=0.021) but the association with other factors was not significant. There was also no significant correlation of parathyroid hormone with any of the other factors. Conclusion: In this study, we concluded that there is no specific and significant direct effect of FGF-23 on metabolism of vitamin-D but serum levels parathyroid hormone, which is a mediator of vitamin D metabolism, was positively associated with FGF-23 level in circulation.

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