Shahid Abdur Rauf, Nazullah, Umer Khan, Tariq Baber.
To compare Oral Tranexamic Acid with Conventional Treatment and Prevention of Secondary Hemorrhage in Traumatic Hyphema.
Ophthalmol Update Jan ;16(2):642-5.

Background: Trauma to the eye may result in various injuries including presence of blood in the anterior chamber without perforation of the eye. Closed-globe traumatic hyphema may cause diverse complications including associated traumatic uveitis which generally accompanies the initiating trauma, secondary hemorrhage, corneal blood staining, synechiae formation, and ocular hypertension /secondary glaucoma. Over 90% of injuries occurred in the home setting, with the most common mechanisms of injury being general play, projectiles from guns, and sports injuries occurring during games or practice.2 Traumatic hyphema is commonly associated with damage to the anterior chamber angle, and the pathological changes seen have been linked with the development of chronic secondary glaucoma.3 Objective: To compare oral tranexamic acid with conventional treatment in prevention of secondary hemorrhage in traumatic hyphema. Materials and Methods: The study was conducted at the Department of Clinical Ophthalmology, Khyber Institute of Ophthalmic Medical Sciences; Post Graduate Medical Institute, Hayatabad Medical Complex, Peshawar from 25/02/2015 to 28/02/2016.It was randomized controlled study. It was a randomized control study. Results: Efficacy among two groups was analyzed in terms of secondary hemorrhage as conventional treatment in Group A and conventional treatment plus oral tranexamic acid in Group B. In Group A, it was effective (no secondary hemorrhage) in 72 (74.22 %) patients and was not effective (secondary hemorrhage) in 25 (25.77%) patients. Whereas in Group B where conventional treatment plus oral tranexamic acid was used, it was effective (no secondary hemorrhage) in 88 (90.72%) patients and was not effective (secondary hemorrhage) in 09 (9.27%) patients. Conclusions: Our study concludes that oral tranexamic acid is more effective as compare to conventional treatment in prevention of secondary hemorrhage in traumatic hyphema.

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