Nasreen Laiq, Shahid Khan, Muhammad Naeem Khan, Roheena Wadood.
Statins markedly Reduces Atrial Fibrillation in patients undergoing Valve Replacement Surgeries.
Ophthalmol Update Jan ;15(4):432-5.

Objective: The primary objective of the study was to determine the strength of evidence for preoperative statin therapy for prevention of AF after cardiac surgery, and to determine the length of stay in Cardiac ICU. Material and Methods: A randomized clinical trial was conducted from June 2015 to July 2016 with patients in the cardiac ICU of Lady Reading Hospital Peshawar Pakistan. 50 patients were enrolled into either of two groups in a randomized way. Group S received statin while Group N received normal saline. The primary outcome measure was the incidence postoperative AF or atrial flutter. Two other outcome measures , length of stay on ventilator and in ICU were also analyzed. Exclusion criteria included history of atrial fibrillation, history of paroxysmal atrial fibrillation, preoperative heart rate of less than 50 beats /min and repeated surgery. Approval for the study was taken from Institutional research and ethical board, Lady Reading Hospital Peshawar. An informed consent was obtained from each patient enrolled in the study. Calculations were done using the SPSS, software pakage,version17, the student `t` test was performed to compare two data. Results were displayed in figures as mean � SD. P values of 0.05 or < 0.05 were considered statistically significant. Results: Patients demographics were almost similar between the two groups. There was no difference in the cross-clamp time and cardiopulmonary bypass times, intra-operative blood gases and haemodynamics were similar between the two groups. (P > 0.05). Time spent on ventilator and length of stay in the intensive care unit (ICU) were significantly reduced in statin versus control group (P < 0.05, Significant). Of the 100 patients in both groups, no serious complications were seen on ventilatory support while discharged from the ICU. Conclusion: Our study provides evidence that preoperative statin therapy is associated with a reduction in the incidence of atrial fibrillation after cardiac surgery.

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