Nesr Farooq, Assad Zaman Khan, Mohammad Naeem Rustam.
Role of Pars Plana Vitrectomy with ILM-Peeling in Diffuse Diabetic Macular Edema.
Ophthalmol Update Jan ;15(4):363-6.

Purpose: To evaluate the benefit of parsplana vitrectomy with ILM peeling in persistent diffuse diabetic macular edema. Design: Prospective randomized comparative clinical trial. Methods: Eyes with diffuse diabetic macular edema from 6-18 months of duration, attached posterior hyaloid and grid laser performed more than 4 months ago were considered for parsplana vitrectomy with ILM peeling. Patients were randomized in to vitrectomy group and control group. Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, retinal thickness using Zeiss stratus OCT were carried at baseline and followed by 1, 3, and 6 months post-operation period. Results: Fifty eyes (100%) were enrolled in the study. Twenty five eyes (50%) were randomized in Vitrectomy group (Gr I) and twenty five eyes (50%) into control group (Gr II). Group I had gender distribution (48% male and 52% female) while in group II (44% were male and 56% were female) and mean age Gr I (51.36 years) and Gr II (51.32 years). Statistical significance improvements were shown in Gr I ETDRS visual acuity (P= .01 to .004). Retinal thickness changes were measured with optical coherence tomography in both groups during follow-up, showed statistically significance in favor of Gr I; P values were <.0001 for month 1,3, and 6. Conclusion: we concluded that ParsPlana Vitrectomy with ILM peeling is beneficial to the patients than observation alone in the treatment of refractory diffuse diabetic macular edema for 6-18 months. However, to rule out any temporary benefits, prolong and large case studies are needed to confirm these findings.

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