Hussain Ahmad Khaqan, Irshad Nabi Sandhu, Hafiz Attique-ur Rehman, Hassan Raza Chaudhary, Abdul Hye.
Recent Advances in the Treatment of Retinoblastoma (Rb).
Ophthalmol Update Jan ;15(3):254-7.
In this study, we have reviewed chemotherapy alternatives for retinoblastoma using intra-arterial, periocular, and intravitreal routes. This review aims to highlight recent advances in the management of Rb that have contributed towards improving treatment outcomes. Noval therapeutic directions are actively being pursued for advanced retinoblastoma cases, as well as treatment developments which decrease the risks of systemic chemo therapy. Recently, the use of targeted delivery of chemotherapy to the eye in the form of selective intra-arterial and intravitreal chemotherapy has shown promising results. However, a multimodal treatment protocol has improved survival in children with extraocular disease. Nevertheless, challenges remain, especially for the developing world. This review aims to highlight recent advances in the management of Rb that have contributed towards improving treatment outcomes.
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