Maira Khan, Rumman Khan, Misbah Durrani, Ghazala Wahid.
Diagnostic Accuracy of Color Doppler Ultrasonography in Evaluation of Breast Lumps for Malignancy (A diagnostic comparative study).
Ophthalmol Update Jan ;15(2):126-30.

Background: Carcinoma breast is the most common cancer among women, second only to lung cancer overall. The objective of this study is to determine the diagnostic accuracy of Doppler ultrasonography in the evaluation of breast lump for malignancy, keeping histopathology as a gold standard. Methods: This study was conducted at the Department of Radiology, Hayatabad Medical Complex Peshawar & Department of Radiology, Mardan Medical Complex, Mardan from November 2013 to May 2014. Patients presenting with breast lump were subjected to colour Doppler ultrasound and then surgical excision of the breast lump for histopathological study was done to confirm the findings on colour Doppler ultrasonography. The data was analysed with SPSS version 10. Sensitivity, Specificity, positive predictive value, negative predictive value were determined by taking histopathology report of breast lump as gold standard. Results: One hundred and fourteen (114) patients were included with age range from 18 to 65 years. Mean age was 43.6 years � 11.23 SD. On colour Doppler ultrasonography, true positive and true negative patients for breast malignancy were 20 (17.54%) and 72 (63.16%) respectively while false positive and false negative patients were 19 (16.67%) and 3 (2.63%) respectively. The sensitivity and specificity colour Doppler ultrasonography were 86.95% and 79.12% respectively while positive and negative predictive values were 51.28% and 96% respectively. The diagnostic accuracy was 80.70%. Conclusion: Color doppler ultrasonography has better sensitivity than specificity and high negative predictive value. Its accuracy in detecting breast malignancy is 89.70%.

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