Imtiaz Ahmed Khattak, Mati-ur Rehman, Zeeshan Saboor Ahmed, Aslam Khan.
Study of Efficacy of Solifenacin for Treatment of Overactive Bladder (OAB) in Women in terms of Frequency to Urinate.
Ophthalmol Update Jan ;14(3):93-7.

Objective: To study the efficacy of solifenacin for treatment of overactive bladder in women in terms of frequency to urinate Study Design: Randomized Controlled Trial (RCT). Study Duration: Study was conducted from 15th July 2015 to 1st March 2016. Sample Size: Sample size of the study was 50 patients in each two groups. Sampling Technique: Non probability consecutive sampling. Methodology: Appropriate investigations of all the patients were performed. Patients were assigned to the two study groups by blocked randomization. Group A was received tab. Ibret folic OD and group B was received Solifenacin 5mg OD plus tab. Ibret folic OD. Both groups were received the treatment for 04 weeks. Data was collected by using structured proforma. Mean age of the patients were 35.78�9.202 ranging from 20 to 50 year of age and mean age in both groups was 37.54�9.679 ranging from 20 to 50 years in Placebo and 34.08�8.535 ranging from 20 to 50 years in Solifenacin group, out of total 100 patients. Results: Frequency of urinate from waking in the morning until sleeping at night in placebo group was, 7 or less time was 18(36.0%), 8-14 time 19(38.0%) and 15 or more time was 13(26.0%) while in Solifenacin group was 7 or less time was 13(26.0%), 8-14 time 25(50.0%) and 15 or more time was 12(24.0%) out of 50 patients in each group. Frequency of urinate from sleeping at night until waking in the morning in placebo group was, 0 time 13(26.0%), 01 time 6(12.0%), 02 time was 15(30.0%) and 3 or more time 16(32.0%) while in Solifenacin group was group was, 0 time 14(28.0%), 01 time 12(24.0%), 02 time was 12(24.0%) and 3 or more time 12(24.0%) out of 50 patients in each group. Frequency distribution of efficacy in placebo groups was 18(36.0%) and in Solifenacin group was 32(64.0%) out of 50 patients in each group with chi-square 5.769 and P-value 0.016 Frequency distribution of efficacy between age group was 28(52.8%) in 20 to 35 years and 20(42.6%) in 36 to 50 years out of 100 patients. Conclusion: solifenacin was clinically effective for relieving OAB symptoms, considering the balance between efficacy, patients` well-being, and tolerability and integrates four OAB symptoms into a single score and can be a useful for research and clinical practice.

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