Shams-ur Rehman, Tariq Zubair, Suraya Israr, Subhan Uddin, Gul Sharif.
Haematological Presentation in Hepatitis-C Infection.
Ophthalmol Update Jan ;14(2):91-4.

Objective: To Study the hematological abnormalities in Hepatitis `C` Infection. Material & Methods: This is an observational study conducted in the Department of Medicine and Department of Pathology of Bacha Khan Medical College, MMC Teaching Hospital Mardan from Jan 2014-Nov 2014. The study included a total of 100 chronic Hepatitis C infection patients diagnosed by PCR and Elisa and 50 patients as a control group. Complete blood counts were performed on all these patients by hematology analyzer (Sysmix) Japan. Results: In the present study 30% patients had anemia, hemoglobin (Hb) level was 9.7+.879 g/dl, 20% patients had thrombocytopenia mean platelet counts was 115+15.768x103 /ul and 15% patients had leucopenia with mean total leucocytes count (TLC) count was 3.8+.365x103 / ul counts in these patient were significantly lower than the control group P value for Hb, platelets count and TLC were; P< .0024, P<.0032 P< .0036 respectively. Conclusion: The study concluded that cytopenia is significant finding in Hepatitis `C` infection and these counts further aggravate as the diseases advances to chronic phase. Moreover any patients presenting with cytopenia should be properly screened for HCV infection for prompt diagnosis and treatment the incidence of hepatitis associated cytopenia in this region is high because of dense population and poor hygienic measurements. This further reduces uses of bone marrow aspiration.

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