Yousaf Jamal Mahsood, Mohammad Nazim, Sanaullah Jan.
Comparison of Visual Outcome after Intravitreal Bevacizumab with Standard & alone Management Protocol in Branch Retinal Vein Occlusion.
Ophthalmol Update Jan ;14(1):27-32.

Objective: To compare the visual outcome after Intravitreal Bevacizumab with standard management protocol and with the standard protocol alone in Branch Retinal Vein Occlusion. Study Design: Randomized Controlled Trial Duration & Place: This randomized controlled trial was conducted at Ophthalmology Department, Khyber Institute of Ophthalmic Medical Sciences, Postgraduate Medical Institute, Hayatabad Medical Complex, Peshawar. Duration of study was one year (from 24th March 2010 to 24th March 2011). Materials & Methods: We included 40 subjects in each group with total number of 80 subjects. All patients were investigated for visual acuity, dilated fundus examination with slit-lamp biomicroscopy and 78 D for determining macular edema. Group 1 was intervention group in which each eye received monthly Intravitreal Bevacizumab injection followed by macular laser after 12 weeks. Group 2 was standard group in which the eyes were followed for 12 weeks without any intervention and at 12 weeks follow-up macular laser were applied. Results: In our study, mean age was 58 years. 56% percent patients were male and 44% patients were females. For statistical analysis, Snellen Visual Acuity was converted to LogMAR Visual Acuity. Mean LogMAR Best Corrected Visual Acuity (BCVA) at presentation, 4,8,12 and16 weeks in intervention group was recorded as 0.8, 0.6, 0.5, 0.3 and 0.3 respectively while in standard group it was found to be as 0.8, 0.8, 0.6, 0.5 and 0.3 LogMAR respectively. P-value at each follow-up was found to be 0.999, 0.0001, 0.04, 0.03 and 0.999 between the two groups. Conclusion: Both groups show statistically similar results but combined treatment with Intravitreal Bevacizumab and macular grid photocoagulation provided good results in terms of faster recovery of lost vision and may be considered as an alternative therapy for ME in Branch Retinal Vein Occlusion.

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