Iram Mobusher, Ghazala Saeed.
Efficacy of Metformin to Achieve Menstrual Regularity in PCO patients.
Pak J Med Health Sci Jan ;8(2):394-7.

Aim: To assess the effectiveness of metformin to achieve menstrual regularity in patients with polycystic ovary syndrome. Study design: Descriptive case series. Setting: This study was conducted in outpatient department of Lady Willingdon Hospital Lahore. Duration: Six months from 01-02-2012 to 31-07-2012. Methods: A total of 85 patients of polycystic ovary syndrome were selected for this study. An informed consent was obtained from them for investigating in detail and using their data for research. Demographic history including name, age and address etc. were obtained from all the patients. Metformin was given in dose of 500mg three times a day. Patients were evaluated after three months for achievement of menstrual regularity. Results: The mean age of the patients was 27.4±5.7 years. There were 76(89.4%) patients had oligomenorrhea and 9(10.6%) patients had amenorrhea. In the distribution of patients by efficacy of treatment i.e. regular menstrual cycle achieved after treatment, there were 68(80%) patients in which the treatment was effective and 17(20%) patients in which the treatment was not effective. Conclusion: It is concluded from this study that metformin is effective in patients of polycystic ovary syndrome. It corrects menstrual irregularity in majority of the women with polycystic ovary syndrome.

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